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Duromine or Xenical

Duromine and Xenical medications are approved by the FDA for weight loss. Xenical and Duromine diet pills are prescribed for the treatment of obesity by means of combined therapy, involving low-calorie diet and physical exercises.

Pharmacokinetics of Duromine

Duromine or Xenical

Duromine is a sympathomimetic amine similar to Amphetamine. Duromine weight loss drug possesses anorexigenic effect. Duromine diet pills stimulate the central nervous system by acting on dopaminergic and noradrenergic receptors. Action of Duromine on hypothalamus provides appetite loss.

Duromine is absorbed from the gastrointestinal tract easily. Moderate anorexigenic effect is maintained within 72 hours after the oral intake of Duromine diet pills. The half-life of Duromine out of the body is approximately 25 hours.

Hence, the prolonged therapeutic effect allows taking Duromine diet pills once daily. By taking Duromine just once a day, the patient avoids possible risk of side effects.

Pharmacokinetics of Xenical

Xenical is a strong gastrointestinal lipases inhibitor with a prolonged effect. By acting on gastric and pancreatic lipases, Xenical blocks the ability of inactivated enzymes to split fats that come into the human body with food (triglycerides). Excretion of triglycerides in unsplit form reduces the number of calories in the body, thereby providing weight loss. Therefore, therapeutic effect of Xenical drug involves no absorption in the systemic circulation.

Xenical is poorly absorbed from the GI tract. Xenical is bound to plasma proteins by more than 99% in vitro. As for the Xenical therapeutic action, it starts in 24-48 hours after the oral intake. Xenical metabolism takes place mostly in the intestinal walls. Period of total excretion of Xenical drug is nearly 72 hours after the use of a single Xenical dose.

Duromine manufacturer

Duromine medication was approved by the FDA for the treatment of exogenous obesity in March 1977. The manufacturer of Duromine diet pills is pharmacological company TG United Labs.

Xenical manufacturers

Xenical weight loss drug was approved by the FDA in April 1999. It is known that Hoffmann La Roche developed the molecular formula of Xenical pills and later became the manufacturer of Xenical.

Safety use of Duromine

In 2002 according to the CHMP decision, Duromine was canceled in Europe due to some registered cases of cardiac valve failure associated with the use of Duromine pills. However, Duromine drug for the treatment of exogenous obesity is still available in Australia and New Zealand. Duromine is produced in Australia and New Zealand by 3M Pharmaceuticals Pty Ltd.

Safety use of Xenical

When using Xenical pills, some patients experienced severe toxicity of the liver. In this regard, the CHMP considered the possibility to cancel Xenical weight loss drug on the pharmacological market in EU. Yet there is no confirmation that Xenical pills can actually cause liver toxicity. Thus, the CHMP made a decision not to cancel Xenical drug on EU pharmaceutical market. Still, patient must be aware about any hepatic disorders before starting therapy with Xenical pills.

Duromine dosage

Duromine drug for the treatment of exogenous obesity is made for oral use. It is recommended to take Duromine diet pills in the morning before breakfast. The single dose of Duromine is 30mg.

Xenical dosage

It is recommended to take Xenical drug for the obesity treatment three times a day with food (with every main meal). The single dose of Xenical is 120mg. However, Xenical daily dose must never exceed 360mg.

Contraindications for Duromine

It is not recommended to take Duromine in: advanced atherosclerosis; cardiovascular diseases; glaucoma; hypertension; depressive states; alcohol or drug abuse; therapy with MAO inhibitors (Fluoxetine, Sertraline, Fluvoxamine or Paroxetine) or 14 days after their use; pregnancy and lactation; children's age (under 12 years); elderly patients (over 65 years old).

Contraindications for Xenical

Xenical drug for the obesity treatment is not recommended to be taken in: hypersensitivity to the drug components; cholestasis; chronic malabsorption syndrome; pregnancy and lactation; children and adolescents (under 18 years old).

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